| Post Translational Modifications | Phosphorylation at Tyr-164 inhibits activity and promotes cell survival. |
| Function | Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is also composed of SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer with SPTLC2 or SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. Required for adipocyte cell viability and metabolic homeostasis. |
| Protein Name | Serine Palmitoyltransferase 1Long Chain Base Biosynthesis Protein 1Lcb 1Serine-Palmitoyl-Coa Transferase 1Spt 1Spt1 |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Serine Palmitoyltransferase 1 antibodyAnti-Long Chain Base Biosynthesis Protein 1 antibodyAnti-Lcb 1 antibodyAnti-Serine-Palmitoyl-Coa Transferase 1 antibodyAnti-Spt 1 antibodyAnti-Spt1 antibodyAnti-SPTLC1 antibodyAnti-LCB1 antibody |
Information sourced from Uniprot.org
