| Function | ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles. May be involved in morphological and functional mitochondrial transformations during spermatogenesis. |
| Protein Name | Atpase Family Gene 2 Protein Homolog AAfg2 Aaa Atpase Homolog ARibosome Biogenesis Protein Spata5Spermatogenesis-Associated Factor ProteinSpermatogenesis-Associated Protein 5 |
| Cellular Localisation | CytoplasmMitochondrionCytoskeletonSpindle |
| Alternative Antibody Names | Anti-Atpase Family Gene 2 Protein Homolog A antibodyAnti-Afg2 Aaa Atpase Homolog A antibodyAnti-Ribosome Biogenesis Protein Spata5 antibodyAnti-Spermatogenesis-Associated Factor Protein antibodyAnti-Spermatogenesis-Associated Protein 5 antibodyAnti-AFG2A antibodyAnti-SPAF antibodyAnti-SPATA5 antibody |
Information sourced from Uniprot.org
