||Human, Mouse, Rat
||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-SOX2 (1-140) is suitable for use in Western Blot and Immunofluorescence.
||PBS containing 0.02% Sodium Azide, 50% Glycerol, pH7.3.
||WB 1:500-1:2000IF 1:50-1:200
||Store in a freezer at-20°C and avoid freeze-thaw cycles.
||Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human SOX2 (NP_003097.1).
| Post Translational Modifications || Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation. |
| Function || Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Binds to the proximal enhancer region of NANOG. Critical for early embryogenesis and for embryonic stem cell pluripotency. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. |
| Protein Name || Transcription Factor Sox-2 |
| Database Links || Reactome: R-HSA-2892245Reactome: R-HSA-2892247Reactome: R-HSA-3769402Reactome: R-HSA-452723Reactome: R-HSA-6785807Reactome: R-HSA-8986944 |
| Cellular Localisation || Nucleus |
| Alternative Antibody Names || Anti-Transcription Factor Sox-2 antibodyAnti-SOX2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance