| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sorbin and SH3 domain-containing protein 2 (794-844 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SORBS2 |
| Gene ID: |
8470 |
| Uniprot ID: |
SRBS2_HUMAN |
| Immunogen Region: |
794-844 aa |
| Specificity: |
This antibody detects endogenous levels of SRBS2 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human SRBS2 at the amino acid range 794-844 |
| Post Translational Modifications | Ubiquitinated by CBL. Dephosphorylated by PTPN12. |
| Function | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. |
| Protein Name | Sorbin And Sh3 Domain-Containing Protein 2Arg-Binding Protein 2Argbp2Arg/Abl-Interacting Protein 2Sorbin |
| Cellular Localisation | CytoplasmPerinuclear RegionApical Cell MembraneCell JunctionFocal AdhesionCell ProjectionLamellipodiumFound At The Z-Disk SarcomeresStress FibersDense Bodies And Focal AdhesionIn Pancreatic Acinar CellsLocalized Preferentially To The Apical MembraneColocalized With Vinculin And Filamentous Actin At Focal Adhesions And Lamellipodia Of Pancreatic Cells |
| Alternative Antibody Names | Anti-Sorbin And Sh3 Domain-Containing Protein 2 antibodyAnti-Arg-Binding Protein 2 antibodyAnti-Argbp2 antibodyAnti-Arg/Abl-Interacting Protein 2 antibodyAnti-Sorbin antibodyAnti-SORBS2 antibodyAnti-ARGBP2 antibodyAnti-KIAA0777 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
