| Post Translational Modifications | Ubiquitinated by CBL. Dephosphorylated by PTPN12. |
| Function | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. |
| Protein Name | Sorbin And Sh3 Domain-Containing Protein 2Arg-Binding Protein 2Argbp2Arg/Abl-Interacting Protein 2Sorbin |
| Cellular Localisation | CytoplasmPerinuclear RegionApical Cell MembraneCell JunctionFocal AdhesionCell ProjectionLamellipodiumFound At The Z-Disk SarcomeresStress FibersDense Bodies And Focal AdhesionIn Pancreatic Acinar CellsLocalized Preferentially To The Apical MembraneColocalized With Vinculin And Filamentous Actin At Focal Adhesions And Lamellipodia Of Pancreatic Cells |
| Alternative Antibody Names | Anti-Sorbin And Sh3 Domain-Containing Protein 2 antibodyAnti-Arg-Binding Protein 2 antibodyAnti-Argbp2 antibodyAnti-Arg/Abl-Interacting Protein 2 antibodyAnti-Sorbin antibodyAnti-SORBS2 antibodyAnti-ARGBP2 antibodyAnti-KIAA0777 antibody |
Information sourced from Uniprot.org
