| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase SMURF1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SMURF1 |
| Gene ID: |
57154 |
| Uniprot ID: |
SMUF1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of SMURF1 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human SMURF1 |
| Post Translational Modifications | Auto-ubiquitinated in presence of NDFIP1. Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys-383, leading to its degradation by the proteasome. Lys-383 is the primary ubiquitination site. |
| Function | E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS. Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation. Plays a role in dendrite formation by melanocytes. |
| Protein Name | E3 Ubiquitin-Protein Ligase Smurf1Hsmurf1Hect-Type E3 Ubiquitin Transferase Smurf1Smad Ubiquitination Regulatory Factor 1Smad-Specific E3 Ubiquitin-Protein Ligase 1 |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-2173788Reactome: R-HSA-2173791Reactome: R-HSA-4608870Reactome: R-HSA-5632684Reactome: R-HSA-8939902Reactome: R-HSA-8941858Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Smurf1 antibodyAnti-Hsmurf1 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Smurf1 antibodyAnti-Smad Ubiquitination Regulatory Factor 1 antibodyAnti-Smad-Specific E3 Ubiquitin-Protein Ligase 1 antibodyAnti-SMURF1 antibodyAnti-KIAA1625 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
