| Tissue Specificity | Widely expressed, with highest level in heart and skeletal muscle. Expressed in placenta, brain, lung and spleen, but not in liver. |
| Post Translational Modifications | Autophosphorylated. |
| Function | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence ST-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. |
| Protein Name | Serine/Threonine-Protein Kinase Smg1Smg-1Hsmg-1Lambda/Iota Protein Kinase C-Interacting ProteinLambda-Interacting ProteinNonsense Mediated Mrna Decay-Associated Pi3k-Related Kinase Smg1 |
| Database Links | Reactome: R-HSA-975957 |
| Cellular Localisation | NucleusCytoplasmPresent In The Chromatoid Body |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Smg1 antibodyAnti-Smg-1 antibodyAnti-Hsmg-1 antibodyAnti-Lambda/Iota Protein Kinase C-Interacting Protein antibodyAnti-Lambda-Interacting Protein antibodyAnti-Nonsense Mediated Mrna Decay-Associated Pi3k-Related Kinase Smg1 antibodyAnti-SMG1 antibodyAnti-ATX antibodyAnti-KIAA0421 antibodyAnti-LIP antibody |
Information sourced from Uniprot.org
