| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SMARCAL1 (800-900) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SMARCAL1 |
| Gene ID: |
50485 |
| Uniprot ID: |
SMAL1_HUMAN |
| Immunogen Region: |
800-900 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 800-900 of human SMARCAL1 (NP_001120679.1). |
| Immunogen Sequence: |
VFAELFWNPGVLIQAEDRVH RIGQTSSVGIHYLVAKGTAD DYLWPLIQEKIKVLAEAGLS ETNFSEMTESTDYLYKDPKQ QKIYDLFQKSFEKEGSDMEL L |
| Tissue Specificity | Ubiquitously expressed, with high levels in testis. |
| Post Translational Modifications | DNA damage-regulated phosphorylation by kinases that may include ATM, ATR and PRKDC. |
| Function | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. |
| Protein Name | Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A-Like Protein 1Hepa-Related ProteinHharpSucrose Nonfermenting Protein 2-Like 1 |
| Cellular Localisation | NucleusRecruited To Damaged Dna Regions |
| Alternative Antibody Names | Anti-Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A-Like Protein 1 antibodyAnti-Hepa-Related Protein antibodyAnti-Hharp antibodyAnti-Sucrose Nonfermenting Protein 2-Like 1 antibodyAnti-SMARCAL1 antibodyAnti-HARP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
