| Tissue Specificity | Highly expressed in brain and in Leydig cells in testis. Localized in nests of Leydig cells (at protein level). Expressed in choroid plexus (at protein level). Not strongly enriched in cerebral microvessels. |
| Function | Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane. Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases. Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency. Transports T4 and E1S in a pH-insensitive manner. Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain. |
| Protein Name | Solute Carrier Organic Anion Transporter Family Member 1c1Organic Anion Transporter 1c1Oatp1c1Organic Anion Transporter FOatp-FOrganic Anion Transporter Polypeptide-Related Protein 5Oat-Rp-5Oatp-Rp5Organic Anion-Transporting Polypeptide 14Oatp-14Solute Carrier Family 21 Member 14Thyroxine Transporter |
| Database Links | Reactome: R-HSA-879518 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinExpressed In Both Luminal And Abluminal Membranes Of Brain Capillary Endothelial CellsLocalized To The Apical Membrane And Basal Surfaces Of Choroid Plexus |
| Alternative Antibody Names | Anti-Solute Carrier Organic Anion Transporter Family Member 1c1 antibodyAnti-Organic Anion Transporter 1c1 antibodyAnti-Oatp1c1 antibodyAnti-Organic Anion Transporter F antibodyAnti-Oatp-F antibodyAnti-Organic Anion Transporter Polypeptide-Related Protein 5 antibodyAnti-Oat-Rp-5 antibodyAnti-Oatp-Rp5 antibodyAnti-Organic Anion-Transporting Polypeptide 14 antibodyAnti-Oatp-14 antibodyAnti-Solute Carrier Family 21 Member 14 antibodyAnti-Thyroxine Transporter antibodyAnti-SLCO1C1 antibodyAnti-OATP14 antibodyAnti-OATP1C1 antibodyAnti-OATPF antibodyAnti-SLC21A14 antibody |
Information sourced from Uniprot.org
