| Post Translational Modifications | Glycosylated. Dephosphorylation at Ser-274 and phosphorylation at Ser-297 increase affinity and amino acid transport activity. Phosphorylation-dephosphorylation cycle is regulated by food-entrained diurnal rhythm and dietary proteins. |
| Function | Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine. The transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent. |
| Protein Name | Large Neutral Amino Acids Transporter Small Subunit 4L-Type Amino Acid Transporter 4Solute Carrier Family 43 Member 2 |
| Database Links | Reactome: R-HSA-352230 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneLocated At The Basolateral Membrane In The Small Intestine EnterocytesKidney Proximal TubuleThick Ascending Limb AndTo A Minor ExtentOf Distal Convoluted Tubule Epithelial Cells |
| Alternative Antibody Names | Anti-Large Neutral Amino Acids Transporter Small Subunit 4 antibodyAnti-L-Type Amino Acid Transporter 4 antibodyAnti-Solute Carrier Family 43 Member 2 antibodyAnti-SLC43A2 antibodyAnti-LAT4 antibodyAnti-PP7664 antibody |
Information sourced from Uniprot.org
