| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:200-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC25A39 |
| Gene ID: |
51629 |
| Uniprot ID: |
S2539_HUMAN |
| Immunogen Region: |
170-250 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 170-250 of human SLC25A39 (NP_001137252.1). |
| Immunogen Sequence: |
LARLGTVTVISPLELMRTKL QAQHVSYRELGACVRTAVAQ GGWRSLWLGWGPTALRDVPF SALYWFNYELVKSWLNGFRP K |
| Tissue Specificity | Expressed in many tissues. Abundant in testis and kidney. |
| Post Translational Modifications | Cleaved and degraded by AFG3L2.degradation by AFG3L2 is regulated by the ability of SLC25A39 to bind iron-sulfur. In absence of mitochondrial glutathione, SLC25A39 binds iron-sulfur, preventing cleavage and degradation by AFG3L2. The presence of mitochondrial glutathione prevents iron-sulfur-binding to SLC25A39, promoting cleavage and degradation by AFG3L2. |
| Function | Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis. |
| Protein Name | Mitochondrial Glutathione Transporter Slc25a39Solute Carrier Family 25 Member 39 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Glutathione Transporter Slc25a39 antibodyAnti-Solute Carrier Family 25 Member 39 antibodyAnti-SLC25A39 antibodyAnti-CGI-69 antibodyAnti-PRO2163 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
