| Post Translational Modifications | N-glycosylated. |
| Function | Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions. Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid. Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate. Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption. Orotate transport is Cl(-)-dependent. |
| Protein Name | Solute Carrier Family 22 Member 12Organic Anion Transporter 4-Like ProteinRenal-Specific TransporterRstUrate Anion Exchanger 1Urat1Urate -Anion Antiporter Slc22a12 |
| Database Links | Reactome: R-HSA-561048Reactome: R-HSA-5619071 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Solute Carrier Family 22 Member 12 antibodyAnti-Organic Anion Transporter 4-Like Protein antibodyAnti-Renal-Specific Transporter antibodyAnti-Rst antibodyAnti-Urate Anion Exchanger 1 antibodyAnti-Urat1 antibodyAnti-Urate -Anion Antiporter Slc22a12 antibodyAnti-SLC22A12 antibodyAnti-OATL4 antibodyAnti-URAT1 antibodyAnti-UNQ6453 antibodyAnti-PRO34004 antibody |
Information sourced from Uniprot.org
