| Post Translational Modifications | Phosphorylated at Thr-929 and Thr-1029 by OXSR1/OSR1 and STK39/SPAK downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4), inhibiting the potassium-chloride cotransport activity. |
| Function | Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation. |
| Protein Name | Solute Carrier Family 12 Member 5Electroneutral Potassium-Chloride Cotransporter 2K-Cl Cotransporter 2Mkcc2Neuronal K-Cl Cotransporter |
| Database Links | Reactome: R-MMU-426117 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionDendriteDetected On DendritesBut Not On Axons Of Spinal Cord Neurons And At Gphn-Positive Inhibitory Synapses |
| Alternative Antibody Names | Anti-Solute Carrier Family 12 Member 5 antibodyAnti-Electroneutral Potassium-Chloride Cotransporter 2 antibodyAnti-K-Cl Cotransporter 2 antibodyAnti-Mkcc2 antibodyAnti-Neuronal K-Cl Cotransporter antibodyAnti-Slc12a5 antibodyAnti-Kcc2 antibodyAnti-Kiaa1176 antibody |
Information sourced from Uniprot.org
