| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | SLA |
| Gene ID: | 6503 |
| Uniprot ID: | SLAP1_HUMAN |
| Immunogen Region: | 1-276 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-276 of human SLA (NP_006739.2). |
| Immunogen Sequence: | MLSKLGHSPLGGLRARLTFP VCLLYHRLWASPAAPGKKKE MGNSMKSTPAPAERPLPNPE GLDSDFLAVLSDYPSPDISP PIFRRGEKLRVISDEGGWWK AISLSTGRESYIPGICVARV YHGWLFEGLGRDKAEELLQL PDTKVGSFMIRESETKKGFY SLSVRHRQVKHYRIFRLPNN WYYISPRLTFQCLEDLVNHY SEVADGLCCVLTTPCLTQST AAPAVRASSSPVTLRQKTV |
| Tissue Specificity | Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas. |
| Function | Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. |
| Protein Name | Src-Like-AdapterSrc-Like-Adapter Protein 1Slap-1Hslap |
| Database Links | Reactome: R-HSA-9706369 |
| Cellular Localisation | CytoplasmEndosomeColocalizes With Endosomes |
| Alternative Antibody Names | Anti-Src-Like-Adapter antibodyAnti-Src-Like-Adapter Protein 1 antibodyAnti-Slap-1 antibodyAnti-Hslap antibodyAnti-SLA antibodyAnti-SLAP antibodyAnti-SLAP1 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and BCKDHA knockout (KO) 293T cells, using [KO Validated] BCKDHA Rabbit pAb (STJ11106587) at 1:1000 dilution. <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Basic Kit <br/>Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/185783/407691/STJ11106587_1__02232.1744894218.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and BCKDHA knockout (KO) 293T cells, using [KO Validated] BCKDHA Rabbit pAb (STJ11106587) at 1:1000 dilution. <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Basic Kit <br/>Exposure time: 1s.")