| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SETD1A |
| Gene ID: | 9739 |
| Uniprot ID: | SET1A_HUMAN |
| Immunogen Region: | 258-458 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 258-458 of human SET1A. (O15047). |
| Immunogen Sequence: | SSFGQFTPQSSQGTPYTSRG STPYSQDSAYSSSTTSTSFK PRRSENSYQDAFSRRHFSAS SASTTASTAIAATTAATASS SASSSSLSSSSSSSSSSSSS QFRSSDANYPAYYESWNRYQ RHTSYPPRRATREEPPGAPF AENTAERFPPSYTSYLPPEP SRPTDQDYRPPASEAPPPEP PEPGGGGGGGGPSPEREEVR TSPRPASPARSGSPAPETTN ESVPFAQHSSLDSRIEMLL |
| Function | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis. Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation. Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated. Binds RNAs involved in RNA processing and the DNA damage response. |
| Protein Name | Histone-Lysine N-Methyltransferase Setd1a Lysine N-Methyltransferase 2f Set Domain-Containing Protein 1a Hset1a Set1/Ash2 Histone Methyltransferase Complex Subunit Set1 |
| Database Links | Reactome: R-HSA-3214841 Reactome: R-HSA-8936459 Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus Speckle Chromosome Cytoplasm Localizes To A Largely Non-Overlapping Set Of Euchromatic Nuclear Speckles With Setd1b Suggesting That Setd1a And Setd1b Each Bind To A Unique Set Of Target Genes Predominantly Nuclear |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Setd1a antibody Anti-Lysine N-Methyltransferase 2f antibody Anti-Set Domain-Containing Protein 1a antibody Anti-Hset1a antibody Anti-Set1/Ash2 Histone Methyltransferase Complex Subunit Set1 antibody Anti-SETD1A antibody Anti-KIAA0339 antibody Anti-KMT2F antibody Anti-SET1 antibody Anti-SET1A antibody |
Information sourced from Uniprot.org