| Function | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis. Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation. Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated. Binds RNAs involved in RNA processing and the DNA damage response. |
| Protein Name | Histone-Lysine N-Methyltransferase Setd1aLysine N-Methyltransferase 2fSet Domain-Containing Protein 1aHset1aSet1/Ash2 Histone Methyltransferase Complex Subunit Set1 |
| Database Links | Reactome: R-HSA-3214841Reactome: R-HSA-8936459Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus SpeckleChromosomeCytoplasmLocalizes To A Largely Non-Overlapping Set Of Euchromatic Nuclear Speckles With Setd1bSuggesting That Setd1a And Setd1b Each Bind To A Unique Set Of Target GenesPredominantly Nuclear |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Setd1a antibodyAnti-Lysine N-Methyltransferase 2f antibodyAnti-Set Domain-Containing Protein 1a antibodyAnti-Hset1a antibodyAnti-Set1/Ash2 Histone Methyltransferase Complex Subunit Set1 antibodyAnti-SETD1A antibodyAnti-KIAA0339 antibodyAnti-KMT2F antibodyAnti-SET1 antibodyAnti-SET1A antibody |
Information sourced from Uniprot.org
