| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Heparin cofactor 2 (41-90 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:5000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SERPIND1 |
| Gene ID: | 3053 |
| Uniprot ID: | HEP2_HUMAN |
| Immunogen Region: | 41-90 aa |
| Specificity: | HC-II Polyclonal Antibody detects endogenous levels of HC-II protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Heparin Cofactor II at the amino acid range 41-90 |
| Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
| Function | Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. Isoform 2: Shows negligible inhibition, in vitro, of thrombin and tPA and no inhibition of factor Xa, in vitro. |
| Protein Name | Heparin Cofactor 2 Heparin Cofactor Ii Hc-Ii Protease Inhibitor Leuserpin-2 Hls2 Serpin D1 |
| Database Links | Reactome: R-HSA-140837 Reactome: R-HSA-140875 Reactome: R-HSA-381426 Reactome: R-HSA-8957275 |
| Alternative Antibody Names | Anti-Heparin Cofactor 2 antibody Anti-Heparin Cofactor Ii antibody Anti-Hc-Ii antibody Anti-Protease Inhibitor Leuserpin-2 antibody Anti-Hls2 antibody Anti-Serpin D1 antibody Anti-SERPIND1 antibody Anti-HCF2 antibody |
Information sourced from Uniprot.org