| Post Translational Modifications | Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells.is released both as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein. N-glycosylated. |
| Function | Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG. Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis.protection against apoptosis is probably mediated by MAG. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. |
| Protein Name | Reticulon-4 Receptor-Like 2Nogo Receptor-Like 3Nogo-66 Receptor Homolog 1Nogo-66 Receptor-Related Protein 2Ngr2 |
| Database Links | Reactome: R-HSA-163125 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftCell ProjectionDendritePerikaryonAxonLocalized To The Surface Of NeuronsIncluding AxonsDetected Close To SynapsesBut Is Excluded From Synapses |
| Alternative Antibody Names | Anti-Reticulon-4 Receptor-Like 2 antibodyAnti-Nogo Receptor-Like 3 antibodyAnti-Nogo-66 Receptor Homolog 1 antibodyAnti-Nogo-66 Receptor-Related Protein 2 antibodyAnti-Ngr2 antibodyAnti-RTN4RL2 antibodyAnti-NGRH1 antibodyAnti-NGRL3 antibody |
Information sourced from Uniprot.org
