| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RRP9 (156-475) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RRP9 |
| Gene ID: |
9136 |
| Uniprot ID: |
U3IP2_HUMAN |
| Immunogen Region: |
156-475 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 156-475 of human RRP9 (NP_004695.1). |
| Immunogen Sequence: |
PDDSAIFSAAKDCSIIKWSV ESGRKLHVIPRAKKGAEGKP PGHSSHVLCMAISSDGKYLA SGDRSKLILIWEAQSCQHLY TFTGHRDAVSGLAFRRGTHQ LYSTSHDRSVKVWNVAENSY VETLFGHQDAVAALDALSRE CCVTAGGRDGTVRVWKIPEE SQLVFYGHQGSIDCIHLINE EHMVSGADDGSVALWGLSKK RPLALQREAHGLRGEPGLEQ PFWISSVAALLNTDLVATG |
| Post Translational Modifications | Acetylation at Lys-12 and Lys-25 by KAT2B/PCAF under stress impairs pre-rRNA processing. Deacetylation by SIRT7 enhances RRP9-binding to U3 snoRNA, which is a prerequisite for pre-rRNA processing. |
| Function | Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. |
| Protein Name | U3 Small Nucleolar Rna-Interacting Protein 2Rrp9 HomologU3 Small Nucleolar Ribonucleoprotein-Associated 55 Kda ProteinU3 Snornp-Associated 55 Kda ProteinU3-55k |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-U3 Small Nucleolar Rna-Interacting Protein 2 antibodyAnti-Rrp9 Homolog antibodyAnti-U3 Small Nucleolar Ribonucleoprotein-Associated 55 Kda Protein antibodyAnti-U3 Snornp-Associated 55 Kda Protein antibodyAnti-U3-55k antibodyAnti-RRP9 antibodyAnti-RNU3IP2 antibodyAnti-U355K antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
