| Post Translational Modifications | Acetylation at Lys-12 and Lys-25 by KAT2B/PCAF under stress impairs pre-rRNA processing. Deacetylation by SIRT7 enhances RRP9-binding to U3 snoRNA, which is a prerequisite for pre-rRNA processing. |
| Function | Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. |
| Protein Name | U3 Small Nucleolar Rna-Interacting Protein 2Rrp9 HomologU3 Small Nucleolar Ribonucleoprotein-Associated 55 Kda ProteinU3 Snornp-Associated 55 Kda ProteinU3-55k |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-U3 Small Nucleolar Rna-Interacting Protein 2 antibodyAnti-Rrp9 Homolog antibodyAnti-U3 Small Nucleolar Ribonucleoprotein-Associated 55 Kda Protein antibodyAnti-U3 Snornp-Associated 55 Kda Protein antibodyAnti-U3-55k antibodyAnti-RRP9 antibodyAnti-RNU3IP2 antibodyAnti-U355K antibody |
Information sourced from Uniprot.org
