| Tissue Specificity | Preferentially expressed in placental and colon mucosa. Widely expressed at intermediate or lower levels. |
| Function | As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. |
| Protein Name | Replication Protein A 30 Kda SubunitRp-A P30Replication Factor A Protein 4Rf-A Protein 4 |
| Database Links | Reactome: R-HSA-68962 |
| Cellular Localisation | NucleusLocalizes To Dna Repair Foci After Dna Damage |
| Alternative Antibody Names | Anti-Replication Protein A 30 Kda Subunit antibodyAnti-Rp-A P30 antibodyAnti-Replication Factor A Protein 4 antibodyAnti-Rf-A Protein 4 antibodyAnti-RPA4 antibody |
Information sourced from Uniprot.org
