| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ROR1 |
| Gene ID: |
4919 |
| Uniprot ID: |
ROR1_HUMAN |
| Immunogen Region: |
24-937 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 24-403 of human ROR1 (NP_005003.2). |
| Immunogen Sequence: |
ARGAAAQETELSVSAELVPT SSWNISSELNKDSYLTLDEP MNNITTSLGQTAELHCKVSG NPPPTIRWFKNDAPVVQEPR RLSFRSTIYGSRLRIRNLDT TDTGYFQCVATNGKEVVSST GVLFVKFGPPPTASPGYSDE YEEDGFCQPYRGIACARFIG NRTVYMESLHMQGEIENQIT AAFTMIGTSSHLSDKCSQFA IPSLCHYAFPYCDETSSVPK PRDLCRDECEILENVLCQT |
| Tissue Specificity | Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. |
| Function | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling. |
| Protein Name | Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1Neurotrophic Tyrosine Kinase - Receptor-Related 1 |
| Database Links | Reactome: R-HSA-5140745 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxon |
| Alternative Antibody Names | Anti-Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1 antibodyAnti-Neurotrophic Tyrosine Kinase - Receptor-Related 1 antibodyAnti-ROR1 antibodyAnti-NTRKR1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
