| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase RNF183 (4-54 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RNF183 |
| Gene ID: | 138065 |
| Uniprot ID: | RN183_HUMAN |
| Immunogen Region: | 4-54 aa |
| Specificity: | This antibody detects endogenous levels of RN183 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human RN183 at the amino acid range 4-54 |
| Post Translational Modifications | Autoubiquitinated (in vitro). |
| Function | Acts as an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf183 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinEndoplasmic ReticulumGolgi ApparatusCis-Golgi Network MembraneLysosome Membrane |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf183 antibodyAnti-RNF183 antibody |
Information sourced from Uniprot.org