| Post Translational Modifications | Autoubiquitinated in vitro in the presence of UBE2D1 and UBE2E1. |
| Function | E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway. Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1. Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex. Also involved in protein trafficking and localization. Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2. Does not catalyze ubiquitination of GluA1/GRIA1. Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3. Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B. Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18. Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf167Ring Finger Protein 167 |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type I Membrane ProteinEndosome MembraneEndomembrane SystemSingle-Pass Membrane ProteinCell MembraneTargeted To Cytoplasmic MembranesMainly Localizes To Lysosomal MembraneA Subpopulation Localizes To The Cell Membrane Of NeuronsIsoform 1: Lysosome MembraneIsoform 2: CytoplasmCytosol |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf167 antibodyAnti-Ring Finger Protein 167 antibodyAnti-RNF167 antibodyAnti-RING105 antibodyAnti-LP2254 antibody |
Information sourced from Uniprot.org
