| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RNF13 |
| Gene ID: | 11342 |
| Uniprot ID: | RNF13_HUMAN |
| Immunogen Region: | 204-381 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 204-381 of human RNF13 (NP_009213.1). |
| Immunogen Sequence: | TKFVQDRHRARRNRLRKDQL KKLPVHKFKKGDEYDVCAIC LDEYEDGDKLRILPCSHAYH CKCVDPWLTKTKKTCPVCKQ KVVPSQGDSDSDTDSSQEEN EVTEHTPLLRPLASVSAQSF GALSESRSHQNMTESSDYEE DDNEDTDSSDAENEINEHDV VVQLQPNGERDYNIANTV |
| Tissue Specificity | Widely expressed (at protein level). In normal pancreas, expressed in islets, but not in ducts, nor in acini (at protein level). |
| Post Translational Modifications | Autoubiquitinated. |
| Function | E3 ubiquitin-protein ligase that regulates cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. Also involved in protein trafficking and localization. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf13Ring Finger Protein 13 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinLate Endosome MembraneLysosome MembraneNucleus Inner MembraneUnder Certain ConditionsRelocalizes To Recycling Endosomes And To The Inner Nuclear Membrane |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf13 antibodyAnti-Ring Finger Protein 13 antibodyAnti-RNF13 antibodyAnti-RZF antibody |
Information sourced from Uniprot.org