| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RNF123 |
| Gene ID: | 63891 |
| Uniprot ID: | RN123_HUMAN |
| Immunogen Region: | 1213-1314 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1213-1314 of human RNF123 (NP_071347.2). |
| Immunogen Sequence: | QSYADYISADELAQVEQMLA HLTSASAQAAAASLPTSEED LCPICYAHPISAVFQPCGHK SCKACINQHLMNNKDCFFCK TTIVSVEDWEKGANTSTTSS AA |
| Post Translational Modifications | Ubiquitinated, leading to its degradation. Deubiquitinated by USP19, thereby stimulating CDKN1B ubiquitin-dependent degradation. |
| Function | Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B: acts by catalyzing ubiquitination of the NFKB1 p105 precursor, leading to limited proteasomal degradation of NFKB1 p105 and generation of the active NFKB1 p50 subunit. Functions also as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf123 Kip1 Ubiquitination-Promoting Complex Protein 1 Ring Finger Protein 123 |
| Database Links | Reactome: R-HSA-5689880 Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf123 antibody Anti-Kip1 Ubiquitination-Promoting Complex Protein 1 antibody Anti-Ring Finger Protein 123 antibody Anti-RNF123 antibody Anti-KPC1 antibody Anti-FP1477 antibody |
Information sourced from Uniprot.org