| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RIT1 |
| Gene ID: | 6016 |
| Uniprot ID: | RIT1_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RIT1 (NP_001243749.1). |
| Immunogen Sequence: | SDLKQLRQVTKEEGLALARE FSCPFFETSAAYRYYIDDVF HALVREIRRKEKEAVLAMEK KSKPKNSVWKRLKSPFRKKK DSVT |
| Tissue Specificity | Expressed in many tissues. |
| Function | Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. |
| Protein Name | Gtp-Binding Protein Rit1Ras-Like Protein Expressed In Many TissuesRas-Like Without Caax Protein 1 |
| Database Links | Reactome: R-HSA-187706 |
| Cellular Localisation | Cell Membrane |
| Alternative Antibody Names | Anti-Gtp-Binding Protein Rit1 antibodyAnti-Ras-Like Protein Expressed In Many Tissues antibodyAnti-Ras-Like Without Caax Protein 1 antibodyAnti-RIT1 antibodyAnti-RIBB antibodyAnti-RIT antibodyAnti-ROC1 antibody |
Information sourced from Uniprot.org