Western blot with Anti-RIC8A Antibody (STJ502777) with RIC8A peptide. Antibody at 1:500 dilution in buffer.

Anti-RIC8A antibody (500-535) (STJ502777)

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STJ502777-100
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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-RIC8A (500-535) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Purification: Affinity Purified
Concentration: 0.60-0.75 µg/µl
Dilution Range: WB: 1:250
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: RIC8A
Gene ID: 60626
Uniprot ID: RIC8A_HUMAN
Immunogen Region: 500-535
Immunogen: Synthetic peptide taken within amino acids 500-535 on RIC8A protein
Post Translational Modifications Phosphorylated at Ser-436 and Thr-441 by CK2, stabilizing its interface with G alpha proteins.
Function Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ. Does not fold G(s) G-alpha proteins GNAS nor GNAL. Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Protein Name Chaperone Ric-8a
Synembryn-A
Cellular Localisation Cytoplasm
Cell Cortex
Alternative Antibody Names Anti-Chaperone Ric-8a antibody
Anti-Synembryn-A antibody
Anti-RIC8A antibody

Information sourced from Uniprot.org

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