| Function | Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation. Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. |
| Protein Name | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1Malt Lymphoma-Associated TranslocationParacaspase |
| Database Links | Reactome: R-HSA-1169091Reactome: R-HSA-202424Reactome: R-HSA-2871837Reactome: R-HSA-5607764Reactome: R-HSA-5660668 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusShuttles Between The Nucleus And CytoplasmFound In Perinuclear Structures Together With Bcl10 |
| Alternative Antibody Names | Anti-Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 antibodyAnti-Malt Lymphoma-Associated Translocation antibodyAnti-Paracaspase antibodyAnti-MALT1 antibodyAnti-MLT antibody |
Information sourced from Uniprot.org
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