| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RASSF6 |
| Gene ID: | 166824 |
| Uniprot ID: | RASF6_HUMAN |
| Immunogen Region: | 1-303 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human RASSF6 (NP_001257320.1). |
| Immunogen Sequence: | MTMMAHQYPSWIFINEKTFI TREQLNSLLKTYNIFYENQK NLHILYGETEDGKLIVEGML DIFWGVKRPIQLKIQDEKPF SSFTSMKSSDVFSSKGMTRW GEFDDLYRISELDRTQIPMS EKRNSQEDYLSYHSNTLKPH AKDEPDSPVLYRTMSEAALV RKRMKPLMMDRKERQKNRAS INGHFYNHEIENSPQDFALH IIFATGEQRRLKKTDIPLLQ RLLQGPSEKNARIFLMDKD |
| Tissue Specificity | Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart. |
| Function | Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B. |
| Protein Name | Ras Association Domain-Containing Protein 6 |
| Alternative Antibody Names | Anti-Ras Association Domain-Containing Protein 6 antibodyAnti-RASSF6 antibody |
Information sourced from Uniprot.org