| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PXK |
| Gene ID: | 54899 |
| Uniprot ID: | PXK_HUMAN |
| Immunogen Region: | 1-200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PXK (NP_060241.2). |
| Immunogen Sequence: | MAFMEKPPAGKVLLDDTVPL TAAIEASQSLQSHTEYIIRV QRGISVENSWQIVRRYSDFD LLNNSLQIAGLSLPLPPKKL IGNMDREFIAERQKGLQNYL NVITTNHILSNCELVKKFLD PNNYSANYTEIALQQVSMFF RSEPKWEVVEPLKDIGWRIR KKYFLMKIKNQPKERLVLSW ADLGPDKYLSDKDFQCLIKL |
| Tissue Specificity | Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high levels in the brain, skeletal muscle, spleen and testis. Isoform 7 expression has yet to be demonstrated. |
| Function | Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. |
| Protein Name | Px Domain-Containing Protein Kinase-Like ProteinModulator Of Na -K-AtpaseMonaka |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinAlso Associates With The Plasma MembraneIsoform 3 Is Present Throughout The Cell |
| Alternative Antibody Names | Anti-Px Domain-Containing Protein Kinase-Like Protein antibodyAnti-Modulator Of Na -K-Atpase antibodyAnti-Monaka antibodyAnti-PXK antibody |
Information sourced from Uniprot.org