| Tissue Specificity | Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-cell expression levels are variable among individuals. Not detected in B-cells, naive or helper T-cells, monocytes, nor neutrophils (at protein level). Not detected in dendritic cells. |
| Function | Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. |
| Protein Name | Transmembrane Protein PvrigCd112 ReceptorCd112rPoliovirus Receptor-Related Immunoglobulin Domain-Containing Protein |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Transmembrane Protein Pvrig antibodyAnti-Cd112 Receptor antibodyAnti-Cd112r antibodyAnti-Poliovirus Receptor-Related Immunoglobulin Domain-Containing Protein antibodyAnti-PVRIG antibodyAnti-C7orf15 antibody |
Information sourced from Uniprot.org
