| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:10-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTRH2 |
| Gene ID: | 51651 |
| Uniprot ID: | PTH2_HUMAN |
| Immunogen Region: | 40-179 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-179 of human PTRH2 (NP_057161.1). |
| Immunogen Sequence: | LPKSKTSKTHTDTESEASIL GDSGEYKMILVVRNDLKMGK GKVAAQCSHAAVSAYKQIQR RNPEMLKQWEYCGQPKVVVK APDEETLIALLAHAKMLGLT VSLIQDAGRTQIAPGSQTVL GIGPGPADLIDKVTGHLKLY |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Peptidyl-tRNA hydrolase which releases tRNAs from the ribosome during protein synthesis. Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1. |
| Protein Name | Peptidyl-Trna Hydrolase 2 - MitochondrialPth 2Bcl-2 Inhibitor Of Transcription 1 |
| Database Links | Reactome: R-HSA-5689880 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Peptidyl-Trna Hydrolase 2 - Mitochondrial antibodyAnti-Pth 2 antibodyAnti-Bcl-2 Inhibitor Of Transcription 1 antibodyAnti-PTRH2 antibodyAnti-BIT1 antibodyAnti-PTH2 antibodyAnti-CGI-147 antibody |
Information sourced from Uniprot.org