| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRG3 |
| Gene ID: | 10394 |
| Uniprot ID: | PRG3_HUMAN |
| Immunogen Region: | 18-225 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-225 of human PRG3 (NP_006084.2). |
| Immunogen Sequence: | LHLENDAPHLESLETQADLG QDLDSSKEQERDLALTEEVI QAEGEEVKASACQDNFEDEE AMESDPAALDKDFQCPREED IVEVQGSPRCKICRYLLVRT PKTFAEAQNVCSRCYGGNLV SIHDFNFNYRIQCCTSTVNQ AQVWIGGNLRGWFLWKRFCW TDGSHWNFAYWSPGQPGNGQ GSCVALCTKGGYWRRAQCDK QLPFVCSF |
| Tissue Specificity | Expressed in bone marrow. Not detected in placenta. |
| Function | Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. |
| Protein Name | Proteoglycan 3Eosinophil Major Basic Protein HomologPrepro-Major Basic Protein HomologPrepro-Mbph |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cytoplasmic GranuleLocalized To The Eosinophil Secondary Granule |
| Alternative Antibody Names | Anti-Proteoglycan 3 antibodyAnti-Eosinophil Major Basic Protein Homolog antibodyAnti-Prepro-Major Basic Protein Homolog antibodyAnti-Prepro-Mbph antibodyAnti-PRG3 antibodyAnti-MBPH antibodyAnti-UNQ486 antibodyAnti-PRO1002 antibody |
Information sourced from Uniprot.org