| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRAF2 |
| Gene ID: | 11230 |
| Uniprot ID: | PRAF2_HUMAN |
| Immunogen Region: | 1-50 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-50 of human PRAF2 (NP_009144.1). |
| Immunogen Sequence: | MSEVRLPPLRALDDFVLGSA RLAAPDPCDPQRWCHRVINN LLYYQTNYLL |
| Tissue Specificity | Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in tumor tissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same patient. High expression in neuroblastic tumors. Strongly expressed in Purkinje cells and more moderately in cells of the molecular and the granular layers in the cerebellum. Detected in neuronal cells, but not in non-neuronal cells in the cerebral cortex, hippocampus, and lateral ventricles. |
| Function | May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis. |
| Protein Name | Pra1 Family Protein 2 |
| Cellular Localisation | Endosome MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Pra1 Family Protein 2 antibodyAnti-PRAF2 antibodyAnti-JM4 antibody |
Information sourced from Uniprot.org