| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-POU2F1 (15-290) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POU2F1 |
| Gene ID: |
5451 |
| Uniprot ID: |
PO2F1_HUMAN |
| Immunogen Region: |
15-290 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 15-290 of human POU2F1/OCT1 (NP_001185712.1). |
| Immunogen Sequence: |
NPSETSKPSMESGDGNTGTQ TNGLDFQKQPVPVGGAISTA QAQAFLGHLHQVQLAGTSLQ AAAQSLNVQSKSNEESGDSQ QPSQPSQQPSVQAAIPQTQL MLAGGQITGLTLTPAQQQLL LQQAQAQAQLLAAAVQQHSA SQQHSAAGATISASAATPMT QIPLSQPIQIAQDLQQLQQL QQQNLNLQQFVLVHPTTNLQ PAQFIISQTPQGQQGLLQAQ NLLTQLPQQSQANLLQSQP |
| Tissue Specificity | Ubiquitous. Isoform 2 is lymphocyte-specific. |
| Post Translational Modifications | Phosphorylated by PRKDC. |
| Function | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. |
| Protein Name | Pou Domain - Class 2 - Transcription Factor 1Nf-A1Octamer-Binding Protein 1Oct-1Octamer-Binding Transcription Factor 1Otf-1 |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-6807505Reactome: R-HSA-749476Reactome: R-HSA-76071Reactome: R-HSA-9018519 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pou Domain - Class 2 - Transcription Factor 1 antibodyAnti-Nf-A1 antibodyAnti-Octamer-Binding Protein 1 antibodyAnti-Oct-1 antibodyAnti-Octamer-Binding Transcription Factor 1 antibodyAnti-Otf-1 antibodyAnti-POU2F1 antibodyAnti-OCT1 antibodyAnti-OTF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
