| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DNA-directed RNA polymerase III subunit RPC7 (151-200 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POLR3G |
| Gene ID: |
10622 |
| Uniprot ID: |
RPC7_HUMAN |
| Immunogen Region: |
151-200 aa |
| Specificity: |
POLR3G Polyclonal Antibody detects endogenous levels of POLR3G protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the Internal region of human POLR3G at the amino acid range 151-200 |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF- Kappa-B through the RIG-I pathway. |
| Protein Name | Dna-Directed Rna Polymerase Iii Subunit Rpc7Rna Polymerase Iii Subunit C7Dna-Directed Rna Polymerase Iii Subunit GRna Polymerase Iii 32 Kda Apha SubunitRpc32-AlphaRna Polymerase Iii 32 Kda SubunitRpc32 |
| Database Links | Reactome: R-HSA-1834949Reactome: R-HSA-73780Reactome: R-HSA-73980Reactome: R-HSA-749476Reactome: R-HSA-76061Reactome: R-HSA-76066Reactome: R-HSA-76071 |
| Cellular Localisation | NucleusCytoplasmExcluded From NucleoliIn Zygotes And The 2-Cell Stage EmbryosMainly In The CytoplasmStarts To Localize To The Nucleus In The 8-16 Cell Stage Embryo And Early Blastocysts |
| Alternative Antibody Names | Anti-Dna-Directed Rna Polymerase Iii Subunit Rpc7 antibodyAnti-Rna Polymerase Iii Subunit C7 antibodyAnti-Dna-Directed Rna Polymerase Iii Subunit G antibodyAnti-Rna Polymerase Iii 32 Kda Apha Subunit antibodyAnti-Rpc32-Alpha antibodyAnti-Rna Polymerase Iii 32 Kda Subunit antibodyAnti-Rpc32 antibodyAnti-POLR3G antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
