| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PNLDC1 |
| Gene ID: |
154197 |
| Uniprot ID: |
PNDC1_HUMAN |
| Immunogen Region: |
200-500 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human PNLDC1 (NP_775787.1). |
| Immunogen Sequence: |
DEGVVVKKVSKQHRWYLQNT SCDRESCWKENILLSARGFS VFFQMLVKAQKPLVGHNMMM DLLHLHEKFFRPLPESYDQF KQNIHSLFPVLIDTKSVTKD IWKEMNFPRVSNLSEVYEVL NSDLNPTKNSGPEIVHASRC EKYVETKCPHEAAYDAFLCG SVLLKVAHLLLQKIYHIDPV PESSFPQYLDVLAPYVNQVN LIRAGVPKINFSGPDYPSIR PPILILSVKRWPGVSEQQV |
| Function | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. May act as a regulator of multipotency in embryonic stem cells. Is a critical factor for proper spermatogenesis, involved in pre-piRNAs processing to generate mature piRNAs. |
| Protein Name | Poly(A-Specific Ribonuclease Pnldc1Parn-Like Domain-Containing Protein 1Poly(A-Specific Ribonuclease Domain-Containing Protein 1Hspnldc1 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinLocalizes Mainly In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Poly(A-Specific Ribonuclease Pnldc1 antibodyAnti-Parn-Like Domain-Containing Protein 1 antibodyAnti-Poly(A-Specific Ribonuclease Domain-Containing Protein 1 antibodyAnti-Hspnldc1 antibodyAnti-PNLDC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
