| Tissue Specificity | Highest expression in the placenta. Low levels in small intestine, lung, liver, kidney, thymus and heart. |
| Function | Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. |
| Protein Name | Pleckstrin Homology Domain-Containing Family G Member 6Ph Domain-Containing Family G Member 6Myosin-Interacting Guanine Nucleotide Exchange FactorMyogef |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013149 |
| Cellular Localisation | Cell ProjectionMicrovillusCytoplasmCytoskeletonSpindleSpindle PoleCleavage FurrowDuring MitosisLocalizes To The Spindle PoleCentral Spindle And Cleavage FurrowIn Epithelial CellsRecruited To The Apical Membrane By Ezr Where It Participates In Macropinocytosis |
| Alternative Antibody Names | Anti-Pleckstrin Homology Domain-Containing Family G Member 6 antibodyAnti-Ph Domain-Containing Family G Member 6 antibodyAnti-Myosin-Interacting Guanine Nucleotide Exchange Factor antibodyAnti-Myogef antibodyAnti-PLEKHG6 antibody |
Information sourced from Uniprot.org
