Tissue Specificity | Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain. |
Post Translational Modifications | Phosphorylated by the catalytic subunit of PKA. Phosphorylation of Thr-93 resulted in dissociation of PPP1C from PRIP1. |
Function | Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. |
Protein Name | Inactive Phospholipase C-Like Protein 1Plc-L1Phospholipase C-Deleted In Lung CarcinomaPhospholipase C-Related But Catalytically Inactive ProteinPrip |
Cellular Localisation | Cytoplasm |
Alternative Antibody Names | Anti-Inactive Phospholipase C-Like Protein 1 antibodyAnti-Plc-L1 antibodyAnti-Phospholipase C-Deleted In Lung Carcinoma antibodyAnti-Phospholipase C-Related But Catalytically Inactive Protein antibodyAnti-Prip antibodyAnti-PLCL1 antibody |
Information sourced from Uniprot.org