| Post Translational Modifications | KCNQ2/KCNQ3 heteromeric current can be increased by intracellular cyclic AMP, an effect that depends on phosphorylation of Ser-52 in the N-terminal region. KCNQ2/KCNQ3 are ubiquitinated by NEDD4L. Ubiquitination leads to protein degradation (Probable). Degradation induced by NEDD4L is inhibited by USP36. |
| Function | Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily Kqt Member 2Kqt-Like 2Neuroblastoma-Specific Potassium Channel Subunit Alpha Kvlqt2Voltage-Gated Potassium Channel Subunit Kv7.2 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-445095 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily Kqt Member 2 antibodyAnti-Kqt-Like 2 antibodyAnti-Neuroblastoma-Specific Potassium Channel Subunit Alpha Kvlqt2 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv7.2 antibodyAnti-KCNQ2 antibody |
Information sourced from Uniprot.org
