• Immunohistochemistry analysis of paraffin-embedded human brain, using Kv7.3/KCNQ3 (Phospho-Thr246) Antibody. The picture on the right is blocked with the phospho peptide.

Anti-Phospho-KCNQ2/3/4/5-Thr217/246/223/251 antibody (191-240 aa) (STJ91166)

SKU:
STJ91166

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Potassium voltage-gated channel subfamily KQT member 2 and Potassium voltage-gated channel subfamily KQT member 3 and Potassium voltage-gated channel subfamily KQT member 4 and Potassium voltage-gated channel s
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KCNQ4
KCNQ2
9132
3785
3786
KCNQ4_HUMAN
KCNQ2_HUMAN
KCNQ3_HUMAN
Immunogen Region: 191-240 aa
Specificity: Phospho-KCNQ2/3/4/5 (T217/246/223/251) Polyclonal Antibody detects endogenous levels of KCNQ2/3/4/5 protein only when phosphorylated at T217/246/223/251.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Kv7.3/KCNQ3 around the phosphorylation site of Thr246 at the amino acid range 191-240
Post Translational Modifications KCNQ2/KCNQ3 heteromeric current can be increased by intracellular cyclic AMP, an effect that depends on phosphorylation of Ser-52 in the N-terminal region. KCNQ2/KCNQ3 are ubiquitinated by NEDD4L. Ubiquitination leads to protein degradation (Probable). Degradation induced by NEDD4L is inhibited by USP36.
Function Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1.
Protein Name Potassium Voltage-Gated Channel Subfamily Kqt Member 2
Kqt-Like 2
Neuroblastoma-Specific Potassium Channel Subunit Alpha Kvlqt2
Voltage-Gated Potassium Channel Subunit Kv7.2
Database Links Reactome: R-HSA-1296072
Reactome: R-HSA-445095
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Potassium Voltage-Gated Channel Subfamily Kqt Member 2 antibody
Anti-Kqt-Like 2 antibody
Anti-Neuroblastoma-Specific Potassium Channel Subunit Alpha Kvlqt2 antibody
Anti-Voltage-Gated Potassium Channel Subunit Kv7.2 antibody
Anti-KCNQ2 antibody

Information sourced from Uniprot.org

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