| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Tyrosine-protein kinase Fes/Fps-Tyr713 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FES |
| Gene ID: | 2242 |
| Uniprot ID: | FES_HUMAN |
| Specificity: | This antibody detects endogenous levels of c-Fes (Phospho-Tyr713) at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human c-Fes (Phospho-Tyr713) |
| Tissue Specificity | Widely expressed. Detected in adult colon epithelium (at protein level). Expressed in melanocytes (at protein level). |
| Post Translational Modifications | Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK. |
| Function | Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. |
| Protein Name | Tyrosine-Protein Kinase Fes/Fps Feline Sarcoma/Fujinami Avian Sarcoma Oncogene Homolog Proto-Oncogene C-Fes Proto-Oncogene C-Fps P93c-Fes |
| Database Links | Reactome: R-HSA-1433557 Reactome: R-HSA-399954 Reactome: R-HSA-399955 Reactome: R-HSA-399956 |
| Cellular Localisation | Cytoplasm Cytosol Cytoskeleton Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Cytoplasmic Vesicle Golgi Apparatus Cell Junction Focal Adhesion Distributed Throughout The Cytosol When The Kinase Is Not Activated Association With Microtubules Requires Activation Of The Kinase Activity Shuttles Between Focal Adhesions And Cell-Cell Contacts In Epithelial Cells Recruited To The Lateral Cell Membrane In Polarized Epithelial Cells By Interaction With Phosphorylated Ezr Detected At Tubular Membrane Structures In The Cytoplasm And At The Cell Periphery |
| Alternative Antibody Names | Anti-Tyrosine-Protein Kinase Fes/Fps antibody Anti-Feline Sarcoma/Fujinami Avian Sarcoma Oncogene Homolog antibody Anti-Proto-Oncogene C-Fes antibody Anti-Proto-Oncogene C-Fps antibody Anti-P93c-Fes antibody Anti-FES antibody Anti-FPS antibody |
Information sourced from Uniprot.org