Anti-Phospho-B Raf-T401 antibody [ARC1587] (STJ11102615)

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STJ11102615

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Host: Rabbit
Applications: WB
Reactivity: Human, Mouse, Rat
Short Description: Rabbit monoclonal anti-Phospho-B Raf-T401 antibody is suitable for use in Western Blot.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Monoclonal
Clone ID: ARC1587
Conjugation: Unconjugated
Formulation: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Purification: Affinity purification
Storage Instruction: Store at-20°C. Avoid freeze/thaw cycles.
Isotype: IgG
Dilution Range: WB: 1:500-1:2000
Uniprot ID: BRAF_HUMAN
Gene ID: 673
Gene Symbol: BRAF
Immunogen: A phospho specific peptide corresponding to residues surrounding T401 of human B Raf
Tissue Specificity Brain and testis.
Post Translational Modifications Phosphorylation at Ser-365 by SGK1 inhibits its activity. Methylation at Arg-671 decreases stability and kinase activity. Ubiquitinated by RNF149.which leads to proteasomal degradation. Polyubiquitinated at Lys-578 in response to EGF.
Function Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway. May play a role in the postsynaptic responses of hippocampal neurons.
Protein Name Serine/Threonine-Protein Kinase B-Raf
Proto-Oncogene B-Raf
P94
V-Raf Murine Sarcoma Viral Oncogene Homolog B1
Database Links Reactome: R-HSA-1295596
Reactome: R-HSA-170968
Reactome: R-HSA-170984
Reactome: R-HSA-187706
Reactome: R-HSA-5673000
Reactome: R-HSA-5674135
Reactome: R-HSA-5674499
Reactome: R-HSA-5675221
Reactome: R-HSA-6802946
Reactome: R-HSA-6802948
Reactome: R-HSA-6802952
Reactome: R-HSA-6802955
Reactome: R-HSA-9649948
Reactome: R-HSA-9656223
Reactome: R-HSA-9660537
Cellular Localisation Nucleus
Cytoplasm
Cell Membrane
Colocalizes With Rgs14 And Raf1 In Both The Cytoplasm And Membranes
Alternative Antibody Names Anti-Serine/Threonine-Protein Kinase B-Raf antibody
Anti-Proto-Oncogene B-Raf antibody
Anti-P94 antibody
Anti-V-Raf Murine Sarcoma Viral Oncogene Homolog B1 antibody
Anti-BRAF antibody
Anti-BRAF1 antibody
Anti-RAFB1 antibody

Information sourced from Uniprot.org

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