| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PHIP |
| Gene ID: | 55023 |
| Uniprot ID: | PHIP_HUMAN |
| Immunogen Region: | 1542-1821 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1542-1821 of human PHIP (NP_060404.3). |
| Immunogen Sequence: | KTILENSVKHSKALNTLSSP GQSSFSHGTRNNSAKENMEK EKPVKRKMKSSVLPKASTLS KSSAVIEQGDCKNNALVPGT IQVNGHGGQPSKLVKRGPGR KPKVEVNTNSGEIIHKKRGR KPKKLQYAKPEDLEQNNVHP IRDEVLPSSTCNFLSETNNV KEDLLQKKNRGGRKPKRKMK TQKLDADLLVPASVKVLRRS NRKKIDDPIDEEEEFEELKG SEPHMRTRNQGRRTAFYNE |
| Tissue Specificity | Expressed in myeloma and epidermoid carcinoma cell lines. |
| Function | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. |
| Protein Name | Ph-Interacting ProteinPhipDdb1- And Cul4-Associated Factor 14Irs-1 Ph Domain-Binding ProteinWd Repeat-Containing Protein 11 |
| Database Links | Reactome: R-HSA-9013418 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Ph-Interacting Protein antibodyAnti-Phip antibodyAnti-Ddb1- And Cul4-Associated Factor 14 antibodyAnti-Irs-1 Ph Domain-Binding Protein antibodyAnti-Wd Repeat-Containing Protein 11 antibodyAnti-PHIP antibodyAnti-DCAF14 antibodyAnti-WDR11 antibody |
Information sourced from Uniprot.org