| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PHF20 (140-380) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PHF20 |
| Gene ID: |
51230 |
| Uniprot ID: |
PHF20_HUMAN |
| Immunogen Region: |
140-380 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 140-380 of human PHF20 (NP_057520.2). |
| Immunogen Sequence: |
QNIVGNARPKETDHKSLSSS PDKREKFKEQRKATVNVKKD KEDKPLKTEKRPKQPDKEGK LICSEKGKVSEKSLPKNEKE DKENISENDREYSGDAQVDK KPENDIVKSPQENLREPKRK RGRPPSIAPTAVDSNSQTLQ PITLELRRRKISKGCEVPLK RPRLDKNSSQEKSKNYSENT DKDLSRRRSSRLSTNGTHEI LDPDLVVSDLVDTDPLQDTL SSTKESEEGQLKSALEAGQ |
| Tissue Specificity | Expressed in heart, kidney, liver, lung, pancreas, placenta, spleen and testis. Not expressed in brain, skeletal muscle, colon, ovary, prostate, small intestine and thymus. Expressed in colon and ovary cancer cell lines while it is not expressed in the respective normal tissues. |
| Post Translational Modifications | Ubiquitinated by TRIM26.leading to proteasomal degradation. |
| Function | Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. |
| Protein Name | Phd Finger Protein 20Glioma-Expressed Antigen 2Hepatocellular Carcinoma-Associated Antigen 58Novel Zinc Finger ProteinTranscription Factor Tzp |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-6804757Reactome: R-HSA-6804759Reactome: R-HSA-69541Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Phd Finger Protein 20 antibodyAnti-Glioma-Expressed Antigen 2 antibodyAnti-Hepatocellular Carcinoma-Associated Antigen 58 antibodyAnti-Novel Zinc Finger Protein antibodyAnti-Transcription Factor Tzp antibodyAnti-PHF20 antibodyAnti-C20orf104 antibodyAnti-GLEA2 antibodyAnti-HCA58 antibodyAnti-NZF antibodyAnti-TZP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
