| Function | Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. |
| Protein Name | Phd Finger Protein 10Brg1-Associated Factor 45aBaf45aXap135 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Phd Finger Protein 10 antibodyAnti-Brg1-Associated Factor 45a antibodyAnti-Baf45a antibodyAnti-Xap135 antibodyAnti-PHF10 antibodyAnti-BAF45A antibody |
Information sourced from Uniprot.org
