| Tissue Specificity | Expressed by endometrial glands and stroma (at protein level). Detected in urine (at protein level). |
| Function | Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1. |
| Protein Name | Membrane-Associated Progesterone Receptor Component 2Progesterone Membrane-Binding ProteinSteroid Receptor Protein Dg6 |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013408Reactome: R-HSA-9013423Reactome: R-HSA-9707616 |
| Cellular Localisation | MembraneSingle-Pass Membrane ProteinNucleus EnvelopeEndoplasmic ReticulumSecreted |
| Alternative Antibody Names | Anti-Membrane-Associated Progesterone Receptor Component 2 antibodyAnti-Progesterone Membrane-Binding Protein antibodyAnti-Steroid Receptor Protein Dg6 antibodyAnti-PGRMC2 antibodyAnti-DG6 antibodyAnti-PMBP antibody |
Information sourced from Uniprot.org
