| Tissue Specificity | Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form. |
| Function | Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. |
| Protein Name | Peroxisomal Biogenesis Factor 1933 Kda Housekeeping ProteinPeroxin-19Peroxisomal Farnesylated Protein |
| Database Links | Reactome: R-HSA-1369062Reactome: R-HSA-9603798 |
| Cellular Localisation | CytoplasmPeroxisome MembraneLipid-AnchorCytoplasmic SideMainly CytoplasmicSome Fraction Membrane-Associated To The Outer Surface Of Peroxisomes |
| Alternative Antibody Names | Anti-Peroxisomal Biogenesis Factor 19 antibodyAnti-33 Kda Housekeeping Protein antibodyAnti-Peroxin-19 antibodyAnti-Peroxisomal Farnesylated Protein antibodyAnti-PEX19 antibodyAnti-HK33 antibodyAnti-PXF antibodyAnti-OK antibodyAnti-SW-cl.22 antibody |
Information sourced from Uniprot.org
