Anti-PERP antibody (STJA0009811)

SKU:
STJA0009811
£48.00 - £252.00
Processing The item has been added

Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-p53 apoptosis effector related to PMP-22 is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PERP
Gene ID: 64065
Uniprot ID: PERP_HUMAN
Specificity: This antibody detects endogenous levels of PERP at Human, Mouse
Immunogen: Synthesized peptide derived from human PERP
Function Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Thereby plays a role in barrier function of the skin against infection. Plays a role in mammary epithelial tissue homeostasis and remodeling during and after pregnancy, potentially via its involvement in desmosome cell-cell junctions. Required for tooth enamel development via facilitating desmosome-mediated ameloblast adhesion to the stratum intermedium during the transitional stage of amelogenesis. May also play a role in downstream transcriptional regulation of other genes involved in amelogenesis such as AMBN, ENAM, MMP20 and KLK4. Plays a role as an effector in the TP53-dependent apoptotic pathway. Positively regulates apoptosis in T-helper 17 (Th17) cell populations via caspase-dependent signaling. Promotes neutrophil transepithelial migration in response to chemoattractants such as hepoxilin A3 (HXA3), N-Formylmethionyl-leucyl-phenylalanine (fMLP) and CXCL8/IL-8. Required for neutrophil transepithelial migration in response to S.typhimurium infection. May act as a positive regulator of endothelial cell apoptosis in response to blood flow-derived sheer stress.
Protein Name P53 Apoptosis Effector Related To Pmp-22
Keratinocyte-Associated Protein 1
Kcp-1
P53-Induced Protein Pigpc1
Transmembrane Protein Thw
Database Links Reactome: R-HSA-6803205
Reactome: R-HSA-6809371
Cellular Localisation Cell Junction
Desmosome
Cell Membrane
Multi-Pass Membrane Protein
Cytoplasm
Associated With Desmosomes
Colocalizes With Krt14 In The Cell Membrane
Clusters In A Punctate Pattern Throughout The Epithelial Cytoplasm
In Response To S
Typhimurium Infection
Alternative Antibody Names Anti-P53 Apoptosis Effector Related To Pmp-22 antibody
Anti-Keratinocyte-Associated Protein 1 antibody
Anti-Kcp-1 antibody
Anti-P53-Induced Protein Pigpc1 antibody
Anti-Transmembrane Protein Thw antibody
Anti-PERP antibody
Anti-KCP1 antibody
Anti-KRTCAP1 antibody
Anti-PIGPC1 antibody
Anti-THW antibody

Information sourced from Uniprot.org