| Tissue Specificity | Primarily expressed in liver (at protein level). |
| Post Translational Modifications | Isoform 2 is N-glycosylated with high-mannose oligosaccharides. |
| Function | Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step. Responsible for approximately 30% of hepatic PC with the CDP-choline pathway accounting for the other 70% (Probable). Isoform 1: Catalyzes the three sequential steps of the methylation of 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine (PMME) to 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine (PDME) more efficiently than isoform 2. Induces increase in PC species with longer polyunsaturated chains than isoform 2. Isoform 2: Produces a higher increase in the level of PC species containing long chains with three double bonds than isoform 1. |
| Protein Name | Phosphatidylethanolamine N-MethyltransferasePeamtPemtPemt2Phospholipid MethyltransferasePlmt |
| Database Links | Reactome: R-HSA-1483191 |
| Cellular Localisation | Endoplasmic ReticulumLocalized In The Endoplasmic Reticulum (Er) Of The Liver And In A Lipid Metabolism-Rich Region Of The Er Known As Mitochondria-Associated MembranesAdopts A Topography Within The Er Membrane That Positions Both Termini In The CytosolIsoform 1: Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinMitochondrion MembraneFound In Endoplasmic Reticulum Where Most Pemt Activity Is Generated And In MitochondriaIsoform 2: Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Phosphatidylethanolamine N-Methyltransferase antibodyAnti-Peamt antibodyAnti-Pemt antibodyAnti-Pemt2 antibodyAnti-Phospholipid Methyltransferase antibodyAnti-Plmt antibodyAnti-PEMT antibodyAnti-PEMPT antibodyAnti-PNMT antibody |
Information sourced from Uniprot.org
