Anti-PDIA6 antibody (220aa C-Term) (STJ140160)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant peptide derived from within residues 220 aa to the C-terminus of human PDIA6 produced in E. coli.
General Information
| Short Description | Goat polyclonal Protein disulfide-isomerase A6 (220aa C-Term) antibody for use in WB in human, rat, mouse, canine and monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Goat |
| Reactivity | Human/Rat/Mouse/Canine/Monkey |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 3 mg/mL |
| Purification | This antibody is epitope-affinity purified from goat antiserum. |
| Dilution Range | WB 1:500-1:2000 |
| Formulation | PBS, 20% Glycerol and 0.05% Sodium Azide. |
| Storage Instruction | For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours. |
Target Information
| Gene Symbol | PDIA6 |
| Gene ID | 10130 |
| Uniprot ID | PDIA6_HUMAN |
| Accession Number | ENSG00000143870 |
| Immunogen | Recombinant peptide derived from within residues 220 aa to the C-terminus of human PDIA6 produced in E. coli. |
| Immunogen Region | 220aa C-Term |
| Immunogen Sequence | MDATVNQVLASRYGIRGFPT DATVNQVLASRYGIRGFPTI ATVNQVLASRYGIRGFPTIK TVNQVLASRYGIRGFPTIKI VNQVLASRYGIRGFPTIKIF NQVLASRYGIRGFPTIKIFQ QVLASRYGIRGFPTIKIFQK VLASRYGIRGFPTIKIFQKG LASRYGIRGFPTIKIFQKGE ASRYGIRGFPTIKIFQKGES SRYGIRGFPTIKIFQKGESP |
| Specificity | Detects endogenous levels of PDIA6 by Western blot. |
Additional Info
| Tissue Specificity | Expressed in platelets (at protein level). |
| Function | May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. |
| Protein Name | Protein Disulfide-Isomerase A6Endoplasmic Reticulum Protein 5Er Protein 5Erp5Protein Disulfide Isomerase P5Thioredoxin Domain-Containing Protein 7 |
| Database Links | Reactome: R-HSA-381038Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Endoplasmic Reticulum LumenCell MembraneMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Protein Disulfide-Isomerase A6 antibodyAnti-Endoplasmic Reticulum Protein 5 antibodyAnti-Er Protein 5 antibodyAnti-Erp5 antibodyAnti-Protein Disulfide Isomerase P5 antibodyAnti-Thioredoxin Domain-Containing Protein 7 antibodyAnti-PDIA6 antibodyAnti-ERP5 antibodyAnti-P5 antibodyAnti-TXNDC7 antibody |
Information sourced from Uniprot.org