• Immunohistochemical analysis of paraffin-embedded Human Lung Carcinoma using P53 (Mono Methyl Lys370) Mouse mAb diluted at 1:500.

Anti-P53 (Mono Methyl Lys370) antibody (STJ97495)

Current Stock:
Host: Mouse
Applications: IHC-P
Reactivity: Human, Rat, Mouse
Short Description: Mouse monoclonal primary antibody against P53 (Mono Methyl Lys370).
Clonality: Monoclonal
Clone ID: Q59
Conjugation: Unconjugated
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using a epitope-specific immunogen.
Storage Instruction: Store at-20°C, and avoid repeat freeze-thaw cycles.
Concentration: 1 mg/ml
Isotype: IgG1
Dilution Range: IHC-p 1:50-1:200
WB 500-2000
Specificity: The antibody detects endogenous P53 (Mono Methyl Lys370) protein
Uniprot ID: P53_HUMAN
Gene ID: 7157
Gene Symbol: TP53
Immunogen: Synthetic Peptide
Tissue Specificity Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine.
Database Links Reactome: R-HSA-111448
Cellular Localisation Cytoplasm
Pml Body
Endoplasmic Reticulum
Mitochondrion Matrix
Microtubule Organizing Center
Interaction With Banp Promotes Nuclear Localization
Recruited Into Pml Bodies Together With Chek2
Translocates To Mitochondria Upon Oxidative Stress
Translocates To Mitochondria In Response To Mitomycin C Treatment
Isoform 1: Nucleus
Predominantly Nuclear But Localizes To The Cytoplasm When Expressed With Isoform 4
Isoform 2: Nucleus
Localized Mainly In The Nucleus With Minor Staining In The Cytoplasm
Isoform 3: Nucleus
Localized In The Nucleus In Most Cells But Found In The Cytoplasm In Some Cells
Isoform 4: Nucleus
Predominantly Nuclear But Translocates To The Cytoplasm Following Cell Stress
Isoform 7: Nucleus
Isoform 8: Nucleus
Localized In Both Nucleus And Cytoplasm In Most Cells
In Some Cells
Forms Foci In The Nucleus That Are Different From Nucleoli
Isoform 9: Cytoplasm
Protein Name Cellular Tumor Antigen P53
Antigen Ny-Co-13
Phosphoprotein P53
Tumor Suppressor P53
Alternative Names Anti-Cellular Tumor Antigen P53 antibody
Anti-Antigen Ny-Co-13 antibody
Anti-Phosphoprotein P53 antibody
Anti-Tumor Suppressor P53 antibody
Anti-TP53 antibody
Anti-P53 antibody

Information sourced from Uniprot.org

6 months standard