| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | OCRL |
| Gene ID: | 4952 |
| Uniprot ID: | OCRL_HUMAN |
| Immunogen Region: | 1-220 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human OCRL (NP_001578.2). |
| Immunogen Sequence: | MEPPLPVGAQPLATVEGMEM KGPLREPCALTLAQRNGQYE LIIQLHEKEQHVQDIIPINS HFRCVQEAEETLLIDIASNS GCKIRVQGDWIRERRFEIPD EEHCLKFLSAVLAAQKAQSQ LLVPEQKDSSSWYQKLDTKD KPSVFSGLLGFEDNFSSMNL DKKINSQNQPTGIHREPPPP PFSVNKMLPREKEASNKEQP KVTNTMRKLFVPNTQSGQRE |
| Tissue Specificity | Brain, skeletal muscle, heart, kidney, lung, placenta and fibroblasts. Expressed in the retina and the retinal pigment epithelium. |
| Function | Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling. |
| Protein Name | Inositol Polyphosphate 5-Phosphatase Ocrl Inositol Polyphosphate 5-Phosphatase Ocrl-1 Ocrl-1 Lowe Oculocerebrorenal Syndrome Protein Phosphatidylinositol 3 -4 -5-Triphosphate 5-Phosphatase |
| Database Links | Reactome: R-HSA-1660499 Reactome: R-HSA-1660514 Reactome: R-HSA-1855183 Reactome: R-HSA-1855204 Reactome: R-HSA-432722 Reactome: R-HSA-8856828 Reactome: R-HSA-9013409 Reactome: R-HSA-9013423 |
| Cellular Localisation | Cytoplasmic Vesicle Phagosome Membrane Early Endosome Membrane Membrane Clathrin-Coated Pit Cell Projection Cilium Photoreceptor Outer Segment Endosome Golgi Apparatus Trans-Golgi Network Lysosome Also Found On Macropinosomes Colocalized With Appl1 On Phagosomes |
| Alternative Antibody Names | Anti-Inositol Polyphosphate 5-Phosphatase Ocrl antibody Anti-Inositol Polyphosphate 5-Phosphatase Ocrl-1 antibody Anti-Ocrl-1 antibody Anti-Lowe Oculocerebrorenal Syndrome Protein antibody Anti-Phosphatidylinositol 3 -4 -5-Triphosphate 5-Phosphatase antibody Anti-OCRL antibody Anti-OCRL1 antibody |
Information sourced from Uniprot.org